Bookmark
Forward
Gemcitabine and Pemetrexed disodium in treating breast cancer.
Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA.
Oncology (Williston Park, N.Y.) 2001 FebSizes of these terms reflect their relevance to your search.
Pemetrexed disodium (Alimta, LY231514) is a novel, multitargeted antifolate that inhibits thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyl transferase. This agent is broadly active in a wide variety of solid tumors, including breast cancer. Pemetrexed disodium has also shown clinically relevant activity in combination with gemcitabine (Gemzar). This combination is being evaluated for the treatment of metastatic breast cancer.
Citation
A A Adjei. Gemcitabine and Pemetrexed disodium in treating breast cancer. Oncology (Williston Park, N.Y.). 2001 Feb;15(2 Suppl 3):34-7
Mesh Tags
Substances
PMID: 11252887
View Full Text
