Selective lipoxygenase inhibitor reduces bile acid-induced gastric mucosal injury.

T R Sullivan, J A Cordero, D W Mercer, W P Ritchie, D T Dempsey

Department of Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.

The Journal of surgical research 1992 Dec

filter terms:

Leukotriene receptor blockade attenuates topical bile acid-induced gastric mucosal injury, suggesting that peptidyl-leukotrienes may be mediators of this injury. The purpose of this study was to test the hypothesis that a selective 5-lipoxygenase inhibitor protects against bile acid-induced gastric epithelial injury in the rat. Prior to injury with 10 and 20 mM acidified taurocholate (pH 1.2), rat stomachs were pretreated with either vehicle or WY50295K (selective 5-lipoxygenase inhibitor, 20 mg/kg). Injury was assessed by measuring net transmucosal hydrogen ion flux, luminal appearance of DNA, and gross mucosal injury. Topical 5-lipoxygenase inhibitor significantly reduced luminal H+ ion loss, surface epithelial cell loss (as measured by luminal accumulation of DNA), and gross mucosal injury in bile acid-injured stomachs compared to controls. This study lends further support to the hypothesis that leukotrienes may be mediators of bile acid-induced gastric mucosal injury.

Citation

T R Sullivan, J A Cordero, D W Mercer, W P Ritchie, D T Dempsey. Selective lipoxygenase inhibitor reduces bile acid-induced gastric mucosal injury. The Journal of surgical research. 1992 Dec;53(6):568-71