Efficacy and pharmacokinetics of fluvoxamine maleate in patients with mild depression undergoing hemodialysis.

Toshiko Kamo, Naoshi Horikawa, Yukio Tsuruta, Misako Miyasita, Hiroshi Hatakeyama, Yasuhiko Maebashi

Department of Psychiatry, Tokyo Women's Medical University and Tsuruta Clinic, Tokyo, Japan. tkano@psy.twmu.ac.jp

Psychiatry and clinical neurosciences 2004 Apr

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Seven Japanese patients on maintenance hemodialysis who were comorbid with mild depression were medicated with 50 mg/day fluvoxamine maleate for 28 days. Effectiveness was obtained in four out of seven patients (57%). The plasma fluvoxamine concentrations were examined in three patients. The plasma fuvoxamine concentration decreased by 22% by hemodialysis. There is a tendency for the dialyzed rate of fluvoxamine to become lower if the plasma albumin concentration is higher. The half-life of fluvoxamine was possibly shortened more in the patient with hypoalbuminaemia. The plasma fluvoxamine concentration reached a steady state 8 days after the start of medication and thereafter. The time required to reach steady state was lengthened when compared with the results in normal Japanese volunteers.

Citation

Toshiko Kamo, Naoshi Horikawa, Yukio Tsuruta, Misako Miyasita, Hiroshi Hatakeyama, Yasuhiko Maebashi. Efficacy and pharmacokinetics of fluvoxamine maleate in patients with mild depression undergoing hemodialysis. Psychiatry and clinical neurosciences. 2004 Apr;58(2):133-7