Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus.

Nicole Wolter, Anthony M Smith, David J Farrell, William Schaffner, Matthew Moore, Cynthia G Whitney, James H Jorgensen, Keith P Klugman

Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, P.O. Box 1038, Johannesburg, 2000, South Africa. nicole.edmondson@nhls.ac.za

Antimicrobial agents and chemotherapy 2005 Aug

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Two clinical Streptococcus pneumoniae isolates, identified as resistant to macrolides and chloramphenicol and nonsusceptible to linezolid, were found to contain 6-bp deletions in the gene encoding riboprotein L4. The gene transformed susceptible strain R6 so that it exhibited such resistance, with the transformants also showing a fitness cost. We demonstrate a novel bacterial mechanism of resistance to chloramphenicol and nonsusceptibility to linezolid.

Citation

Nicole Wolter, Anthony M Smith, David J Farrell, William Schaffner, Matthew Moore, Cynthia G Whitney, James H Jorgensen, Keith P Klugman. Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus. Antimicrobial agents and chemotherapy. 2005 Aug;49(8):3554-7