Stereochemistry of pladienolide B.

Naoki Asai, Yoshihiko Kotake, Jun Niijima, Yoshio Fukuda, Taisuke Uehara, Takashi Sakai

Tsukuba Research Laboratories, Eisai Co., Ltd, Tokodai, Tsukuba, Ibaraki, Japan. n2-asai@hhc.eisai.co.jp

The Journal of antibiotics 2007 Jun

filter terms:

Pladienolide B is a 12-membered macrolide isolated from Streptomyces platensis Mer-11107. It showed potent in vitro and in vivo antitumor activities and is a potential lead for novel antitumor agents. The absolute configurations at ten chiral centers were determined on the basis of spectral data of pladienolide B and its chemical transformation products.

Citation

Naoki Asai, Yoshihiko Kotake, Jun Niijima, Yoshio Fukuda, Taisuke Uehara, Takashi Sakai. Stereochemistry of pladienolide B. The Journal of antibiotics. 2007 Jun;60(6):364-9