Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro.

Yasir Hasan Siddique, Gulshan Ara, Tanveer Beg, Mohammad Afzal

Department of Zoology, Section of Genetics, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202 002, India. yasir_hasansiddique@rediffmail.com

Journal of environmental biology / Academy of Environmental Biology, India 2007 Apr

filter terms:

Antioxidants and plant products are reported to reduce the genotoxic damage of steroids. In our present study we have tested different dosages of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in the presence of S9 mix. Treatments with nordihydroguaiaretic acid (NDGA) results in the reduction of the genotoxic damage. A significant decrease was observed at all the tested doses of NDGA in sister chromatic exchanges of number of abnormal cells. The results suggest a protective role of NDGA against the genotoxic damage.

Citation

Yasir Hasan Siddique, Gulshan Ara, Tanveer Beg, Mohammad Afzal. Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro. Journal of environmental biology / Academy of Environmental Biology, India. 2007 Apr;28(2):279-82