WIN 27,147-2 in the treatment of depression. An uncontrolled clinical study.

J N Nestoros, T A Ban, H E Lehmann

International pharmacopsychiatry 1977

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An uncontrolled clinical study with WIN 27,147-2 was conducted with 10 hospitalized depressed psychiatric patients. There was statistically significant improvement in the total scores of the HAM-D, BPRS and Zung; in the scores of all the factors of the HAM-D and Zung; in the scores of the anxiety/depression and activation factors of the BPRS, and in the scores of 6 of the 18 items of the BPRS. Judged by clinical global impression, 9 of the 10 patients were very much improved and 1 patient much improved. The most frequently occurring adverse effects were dry mouth, sweating, drowsiness and insomnia.

Citation

J N Nestoros, T A Ban, H E Lehmann. WIN 27,147-2 in the treatment of depression. An uncontrolled clinical study. International pharmacopsychiatry. 1977;12(2):86-94