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DNMT3A mutations in acute myeloid leukemia.
Mrinal Y Shah, Jonathan D Licht
Division of Hematology and Oncology, Northwestern University, Chicago, Illinois, USA.
Nature genetics 2011 AprSizes of these terms reflect their relevance to your search.
New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.
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Mrinal Y Shah, Jonathan D Licht. DNMT3A mutations in acute myeloid leukemia. Nature genetics. 2011 Apr;43(4):289-90
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PMID: 21445072
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