Poly-lactic acid synthesis for application in biomedical devices - a review.

Astrid J R Lasprilla, Guillermo A R Martinez, Betânia H Lunelli, André L Jardini, Rubens Maciel Filho

School of Chemical Engineering, State University of Campinas, Campinas, Brazil.

Biotechnology advances 2012 Jan-Feb

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Bioabsorbable polymers are considered a suitable alternative to the improvement and development of numerous applications in medicine. Poly-lactic acid (PLA,) is one of the most promising biopolymers due to the fact that the monomers may produced from non toxic renewable feedstock as well as is naturally occurring organic acid. Lactic acid can be made by fermentation of sugars obtained from renewable resources as such sugarcane. Therefore, PLA is an eco-friendly product with better features for use in the human body (nontoxicity). Lactic acid polymers can be synthesized by different processes so as to obtain products with an ample variety of chemical and mechanical properties. Due to their excellent biocompatibility and mechanical properties, PLA and their copolymers are becoming widely used in tissue engineering for function restoration of impaired tissues. In order to maximize the benefits of its use, it is necessary to understand the relationship between PLA material properties, the manufacturing process and the final product with desired characteristics. In this paper, the lactic acid production by fermentation and the polymer synthesis such biomaterial are reviewed. The paper intends to contribute to the critical knowledge and development of suitable use of PLA for biomedical applications. Copyright © 2011 Elsevier Inc. All rights reserved.

Citation

Astrid J R Lasprilla, Guillermo A R Martinez, Betânia H Lunelli, André L Jardini, Rubens Maciel Filho. Poly-lactic acid synthesis for application in biomedical devices - a review. Biotechnology advances. 2012 Jan-Feb;30(1):321-8