Nobuhiro Misumi, Mikako Hiraike, Fusako Nawata, Mirai Hashimoto, Kayoko Tanigawa, Izumi Takase, Aya Nabeshima, Shinobu Honda
Dept. of Pharmacy, National Hospital Organization Kumamoto Medical Center, Japan.
Gan to kagaku ryoho. Cancer & chemotherapy 2011 JulIt is wellknown that cholinomimetic side effects, such as sedation, abdominal pain, nasal flow and watery eyes, may develop in patients in the early stage of Irinotecan (CPT-11) administration; however, there have been no investigations concerning methods for preventing the development of these side effects. To assess the protective effects of pre-treatment with d-CM on cholinomimetic side effects in the early stage after Irinotecan (CPT-11) administration, we prescribed d- Chlorpheniramine maleate (d-CM) to a group of patients prior to Irinotecan (CPT-11) administration. Twenty members from the group of non-d-CM-treated patients (n=39) and 4 members from the group of treated patients (n=20) complained of side effects. The pre-administration of d-CM significantly reduced the number of patients with side effects (p<0.05). The relative risk (RR) for the frequency of side effects was 0.39 (95% CI; 0.15-0.98), demonstrating that the frequency of side effects was significantly reduced. Based on theses findings, we concluded that the pre-administration of d-CM had protective effects against side effects that might develop in the early stage after Irinotecan (CPT-11) administration.
Nobuhiro Misumi, Mikako Hiraike, Fusako Nawata, Mirai Hashimoto, Kayoko Tanigawa, Izumi Takase, Aya Nabeshima, Shinobu Honda. Protective effects of d-chlorpheniramine maleate pre-treatment against acute side effects of Irinotecan(CPT- 11)]. Gan to kagaku ryoho. Cancer & chemotherapy. 2011 Jul;38(7):1149-53
PMID: 21772100
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