Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells.

Lujia Gribben, Robert C Baxter, Deborah J Marsh

Hormones & Cancer Division, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia.

Cancer letters 2012 Apr 1

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Cell migration and invasion leading to metastasis is a major cause of death from endometrial cancer (EC). We have shown that the rate of EC cell migration is inversely related to the level of insulin-like growth factor protein-3 (IGFBP-3). Down-regulation of IGFBP-3 by siRNA in EC cells accelerated migration without affecting proliferation and cells displayed a more migratory phenotype, with co-localization of migration-associated markers at the leading edge of cell membranes. Opposite effects were seen with either the addition of recombinant IGFBP-3 or overexpression of IGFBP-3. Cells with mutated PTEN had the highest IGFBP-3 expression and the slowest migration rates. This study demonstrates that endogenous IGFBP-3 modulates adhesion-migration dynamics in EC cells, implying that it may be important in regulating metastasis in this disease. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Citation

Lujia Gribben, Robert C Baxter, Deborah J Marsh. Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells. Cancer letters. 2012 Apr 1;317(1):41-8