A simple and effective approach to the synthesis of isoquinoline derivatives under solvent-free conditions.

Zinatossadat Hossaini, Faramarz Rostami-Charati, Somayeh Firoziyan, Maryam Sabbaghan, Mohammad A Khalilzadeh

Department of Chemistry, Qaemshahr Branch, Islamic Azad University, P.O. Box 163, Qaemshahr, Iran.

Combinatorial chemistry & high throughput screening 2012 Jul

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An efficient synthesis of dialkyl pyrrolo[2,1-a]isoquinoline-2,3-dicarboxylates, pyrrolo[1,2-a]quinoline-1,2- dicarboxylates and indolizines is described via one-pot reactions of isoquinoline, quinoline or pyridine and phenacyl bromids with dialkyl acetylenedicarboxylates or diaryloylacetylene under solvent-free conditions at 50°C. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods.

Citation

Zinatossadat Hossaini, Faramarz Rostami-Charati, Somayeh Firoziyan, Maryam Sabbaghan, Mohammad A Khalilzadeh. A simple and effective approach to the synthesis of isoquinoline derivatives under solvent-free conditions. Combinatorial chemistry & high throughput screening. 2012 Jul;15(6):503-8