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Dengue is characterized by biphasic fever, myalgia or arthralgia, rash, leukopenia, and lymphadenopathy. It is self-limiting, and dengue-associated haemophagocytic lymphohistiocytosis has been reported in fewer than 20 children worldwide. We report the case of a 4-y-old boy with dengue who continued to have fever for 30 days, with hepatomegaly, thrombocytopenia, and leukopenia. Bone marrow examination showed haemophagocytes. The child was treated with steroids, instead etoposide and oral cyclosporine.


Muznah Kapdi, Ira Shah. Dengue and haemophagocytic lymphohistiocytosis. Scandinavian journal of infectious diseases. 2012 Sep;44(9):708-9

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PMID: 22264033

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