Dendrimer D5 is a vector for peptide transport to brain cells.

S V Sarantseva, O I Bolshakova, S I Timoshenko, A A Kolobov, A L Schwarzman

B. P. Konstantinov Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Leningrad region, Gatchina, Russia. svesar1@yandex.ru

Bulletin of experimental biology and medicine 2011 Feb

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Dendrimers are a new class of nonviral vectors for gene or drug transport. Dendrimer capacity to penetrate through the blood-brain barrier remaines little studied. Biotinylated polylysine dendrimer D5, similarly to human growth hormone biotinylated fragment covalently bound to D5 dendrimer, penetrates through the blood-brain barrier and accumulates in Drosophila brain after injection into the abdomen. Hence, D5 dendrimer can serve as a vector for peptide transport to brain cells.

Citation

S V Sarantseva, O I Bolshakova, S I Timoshenko, A A Kolobov, A L Schwarzman. Dendrimer D5 is a vector for peptide transport to brain cells. Bulletin of experimental biology and medicine. 2011 Feb;150(4):429-31