Regulation of Parkin E3 ubiquitin ligase activity.

Parkin is an E3 ubiquitin ligase mutated in autosomal recessive juvenile Parkinson's disease. In addition, it is a putative tumour suppressor, and has roles outside its enzymatic activity. It is critical for mitochondrial clearance through mitophagy, and is an essential protein in most eukaryotes. As such, it is a tightly controlled protein, regulated through an array of external interactions with multiple proteins, posttranslational modifications including phosphorylation and S-nitrosylation, and self-regulation through internal associations. In this review, we highlight some of the recent studies into Parkin regulation and discuss future challenges for gaining a full molecular understanding of the regulation of Parkin E3 ligase activity.

Citation

Helen Walden, R Julio Martinez-Torres. Regulation of Parkin E3 ubiquitin ligase activity. Cellular and molecular life sciences : CMLS. 2012 Sep;69(18):3053-67

Mesh Tags

Substances

PMID: 22527713

search → result