Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues.
Yasinalli Tamboli, Loretta Lazzarato, Elisabetta Marini, Stefano Guglielmo, Michela Novelli, Pascale Beffy, Pellegrino Masiello, Roberta Fruttero, Alberto Gasco
Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Torino, Italy.
Bioorganic & medicinal chemistry letters 2012 Jun 1We describe a new class of NO-donor hypoglycemic products obtained by joining tolbutamide, a typical hypoglycemic sulfonylurea, with a NO-donor moiety through a hard link. As NO-donors we chose either furoxan (1,2,5-oxadiazole 2-oxide) derivatives or the classical nitrooxy function. A preliminary biological characterization of these compounds, including stimulation of insulin release from cultured rat pancreatic β-cells and in vitro vasodilator and anti-aggregatory activities, is reported. Copyright © 2012 Elsevier Ltd. All rights reserved.
Citation
Yasinalli Tamboli, Loretta Lazzarato, Elisabetta Marini, Stefano Guglielmo, Michela Novelli, Pascale Beffy, Pellegrino Masiello, Roberta Fruttero, Alberto Gasco. Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues. Bioorganic & medicinal chemistry letters. 2012 Jun 1;22(11):3810-5
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PMID: 22565215
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