Kiyohiko Kawai, Mitsuo Hayashi, Tetsuro Majima
The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Japan. kiyohiko@sanken.osaka-u.ac.jp
Journal of the American Chemical Society 2012 Jun 6We report the measurement of hole-transfer rate constants (k(ht)) in locked nucleic acid (LNA) and 5-Me-2'-deoxyzebularine (B)-modified DNA. LNA modification, which makes DNA more rigid, caused a decrease of more than 2 orders of magnitude in k(ht), whereas B modification, which increases DNA flexibility, increased k(ht) by more than 20-fold. The present results clearly showed that hole-transfer efficiency in DNA can be increased by increasing DNA flexibility.
Kiyohiko Kawai, Mitsuo Hayashi, Tetsuro Majima. Hole transfer in LNA and 5-Me-2'-deoxyzebularine-modified DNA. Journal of the American Chemical Society. 2012 Jun 6;134(22):9406-9
PMID: 22591000
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