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Spontaneous remission in 2 children with myelofibrosis, one with megakaryocytic acute myeloblastic leukemia and t(1;22) (with recurrence later) and one with Down syndrome and GATA1 mutation (permanent), are described. One had sepsis and was treated with antibiotics and blood products, whereas the other received only blood products. Remission was spontaneous, without chemotherapy treatment. Possible explanations for these outcomes include immunologic response to sepsis by a leukemia-specific T-cell response or the release of various cytokines, such as tumor necrosis factor and interleukin-2, during infections. Natural killer and cytotoxic T cells transfused with blood products might have also triggered an immune response.


Ronit Elhasid, Tali Tohami, Nivin Moustafa-Hawash, Jonathan Ben-Ezra, Shai Izraeli, Dror Sayar. Spontaneous remission of childhood acute marrow fibrosis and megakaryoblastic leukemia. Journal of pediatric hematology/oncology. 2012 Oct;34(7):565-8

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PMID: 22627572

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