Backbone modification promotes peroxidase activity of G-quadruplex-based DNAzyme.

Cong Li, Ling Zhu, Zhi Zhu, Hao Fu, Gareth Jenkins, Chunming Wang, Yuan Zou, Xin Lu, Chaoyong James Yang

State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.

Chemical communications (Cambridge, England) 2012 Aug 28

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In this work we studied how backbone chemical modifications, such as 2'-O-methyl, phosphorothioate, L-form nucleotides and locked nucleic acid, on G-quadruplex based DNAzymes would affect their peroxidase activity. Our results indicate that 2'-O-methyl modification facilitates the formation of a perfectly compacted parallel structure and significantly promotes peroxidase activity of G-quadruplex based DNAzymes.

Citation

Cong Li, Ling Zhu, Zhi Zhu, Hao Fu, Gareth Jenkins, Chunming Wang, Yuan Zou, Xin Lu, Chaoyong James Yang. Backbone modification promotes peroxidase activity of G-quadruplex-based DNAzyme. Chemical communications (Cambridge, England). 2012 Aug 28;48(67):8347-9