Cloning and characterization of porcine interferon-δ-related genes identified by genomic database screening.

Xin Zhao, Gong Cheng, Ye Jiao, Weiyao Yan, Mingqiu Liu, Zhaoxin Zheng

State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, PR China.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2012 Aug

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Interferon-δ (IFN-δ) belongs to type I IFN. It was first identified by Lefevre in 1993. The porcine interferon-δ (PoIFN-δ)-related sequences were reported in 2009. The IFN-δ-related sequences have not been studied as closely as IFN-α and IFN-β. In this study, we identified 11 functional genes and 7 pseudogenes of the PoIFN-δ-related subtypes from the porcine genome database. Three of these genes were cloned, expressed, and functionally studied. PoIFN-δ-related subtypes can bind to the type I IFN receptors, activate the Janus kinase-signal transduce and activator of transcription (JAK-STAT) sign aling pathway, induce IFN stimulate genes, and other cytokines. The antiviral activity of PoIFN-δ-related subtypes varies a lot in different subtypes. Among all the PoIFN-δ subtypes detected, PoIFN-δ8 has the strongest antiviral and immunomodulatory activities.

Citation

Xin Zhao, Gong Cheng, Ye Jiao, Weiyao Yan, Mingqiu Liu, Zhaoxin Zheng. Cloning and characterization of porcine interferon-δ-related genes identified by genomic database screening. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2012 Aug;32(8):378-85