O I Skiteva, V I Lapteva, O P Balezina
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. oskiteva@gmail.com
Bulletin of experimental biology and medicine 2012 FebRelease of stored calcium ions during activation of ryanodine receptors with ryanodine or caffeine elevates the mean amplitude of spontaneous miniature end-plate potentials. Blockade of these receptors with selective antagonists abolishes this effect. Preliminary loading of the motor nerve terminals with intracellular calcium buffer EGTA-AM, but not with BAPTA-AM, also completely prevented the ryanodine-induced increment of miniature end-plate potential amplitude probably induced by the release of stored calcium. Vesamicol, a selective blocker of acetylcholine transport into vesicles, prevented the ryanodine-induced increment of the mean amplitude of miniature end-plate potentials. This increment was 2-fold more pronounced after preliminary blockade of protein kinase C with chelerythrine and was completely abolished by blockade of protein kinase A with H-89.
O I Skiteva, V I Lapteva, O P Balezina. Role of stored calcium in the regulation of neurotransmitter quantum size. Bulletin of experimental biology and medicine. 2012 Feb;152(4):392-6
PMID: 22803094
View Full Text