Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites.

Ken Cham-Fai Leung, Chun-Pong Chak, Siu-Fung Lee, Josie M Y Lai, Xiao-Ming Zhu, Yi-Xiang J Wang, Kathy W Y Sham, Christopher H K Cheng

Institute of Creativity and Department of Chemistry, The Hong Kong Baptist University, Kowloon, Hong Kong SAR, P. R. China. cfleung@hkbu.edu.hk

Chemical communications (Cambridge, England) 2013 Jan 21

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Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8-10 nm), circular plasmid DNA</a> (~4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.

Citation

Ken Cham-Fai Leung, Chun-Pong Chak, Siu-Fung Lee, Josie M Y Lai, Xiao-Ming Zhu, Yi-Xiang J Wang, Kathy W Y Sham, Christopher H K Cheng. Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites. Chemical communications (Cambridge, England). 2013 Jan 21;49(6):549-51