A 9-year-old boy with chronic urticaria and progressive spondyloarthritis.

Dai Park, Monica L Brown, Peter Densen, Linda K Myers, D Betty Lew

Children's Foundation Research Institute at Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, TN, USA.

Allergy and asthma proceedings : the official journal of regional and state allergy societies 2013 Jan-Feb

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A 9-year-old African American boy presented with chronic urticaria and progressive spondyloarthritis. Laboratory tests were abnormal for persistently positive antinuclear antibodies and undetectable total hemolytic complement (CH50) despite normal levels of complement C2, C3, and C4. Ultimately, further testing revealed an underlying deficiency in the immune system that may be associated with autoimmune disease and thus have a bearing on the patient's urticaria and spondyloarthritis. This is a unique presentation of a rare disease and underscores the importance of evaluating for systemic disease in the workup of chronic urticaria.

Citation

Dai Park, Monica L Brown, Peter Densen, Linda K Myers, D Betty Lew. A 9-year-old boy with chronic urticaria and progressive spondyloarthritis. Allergy and asthma proceedings : the official journal of regional and state allergy societies. 2013 Jan-Feb;34(1):103-7