Risk factors associated with unconjugated neonatal hyperbilirubinemia in Malaysian neonates.

To investigate the risk factors associated with neonatal hyperbilirubinemia in Malaysian neonates. A prospective study was conducted to investigate the effects of glucose-6-phosphate dehydrogenase (G6PD) mutation, variant uridine diphosphate glucuronosyltransferase UGT1A1 gene and hepatic organic anion transporter protein (OATP2) gene on a group of neonates. Hyperbilirubinemia was defined as a total serum bilirubin level of ≥250 µmol/l. Of 318 neonates, 52 (16.4%) had hyperbilirubinemia. The incidence of G6PD mutation was 5.4% (15/280) among these infants. The incidence of G6PD mutation was significantly higher in the male neonates with hyperbilirubinemia (7.8%) when compared with the normal male neonates without hyperbilirubinemia (1.8%; p = 0.03). Logistic regression analysis showed that the significant risk factors for neonatal hyperbilirubinemia were Malay ethnicity [adjusted odds ratio (OR), 2.77; 95% confidence interval (CI): 1.31-5.86; p = 0.007] and G6PD mutation (adjusted OR, 3.29; 95% CI: 1.06-10.1820; p = 0.039). The gender, birth weight and gestation age of neonates, variant c.211G > A and variant of OATP2 gene were not significant. Neonates with Malay ethnicity and G6PD mutation were at risk for hyperbilirubinemia.

Citation

Feiliang Wong, NemYun Boo, Ainoon Othman. Risk factors associated with unconjugated neonatal hyperbilirubinemia in Malaysian neonates. Journal of tropical pediatrics. 2013 Aug;59(4):280-5

PMID: 23640907

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