Membrane anchoring γ-secretase modulators with terpene-derived moieties.
Eva Christine Naumann, Stefan Göring, Isabella Ogorek, Sascha Weggen, Boris Schmidt
Clemens Schöpf-Institute of Organic Chemistry and Biochemistry, Technische Universität Darmstadt, 64287 Darmstadt, Germany.
Bioorganic & medicinal chemistry letters 2013 Jul 1Modulation of γ-secretase activity is a promising therapeutic strategy for the treatment of Alzheimer's disease. Herein we report on the synthesis of carprofen- and tocopherol-derived small-molecule modulators carrying terpene moieties as lipophilic membrane anchors. Additionally, these modulators are equipped with an acidic moiety, which contributes to the desired modulatory effect on the γ-secretase with decreased formation of Aβ42 and increased Aβ38 production. Copyright © 2013 Elsevier Ltd. All rights reserved.
Citation
Eva Christine Naumann, Stefan Göring, Isabella Ogorek, Sascha Weggen, Boris Schmidt. Membrane anchoring γ-secretase modulators with terpene-derived moieties. Bioorganic & medicinal chemistry letters. 2013 Jul 1;23(13):3852-6
PMID: 23707256
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