The balance of protein expression and degradation: an ESCRTs point of view.

Markus Babst, Greg Odorizzi

Current opinion in cell biology 2013 Aug

filter terms:

Endosomal sorting complexes required for transport (ESCRTs) execute the biogenesis of late endosomal multivesicular bodies (MVBs). The ESCRT pathway has traditionally been viewed as a means by which transmembrane proteins are degraded in vacuoles/lysosomes. More recent studies aimed at understanding the broader functions of ESCRTs have uncovered unexpected links with pathways that control cellular metabolism. Central to this communication is TORC1, the kinase complex that controls many of the catabolic and anabolic systems. The connection between TORC1 activity and ESCRTs allows cells to quickly adapt to the stress of nutrient limitations until the longer-term autophagic pathway is activated. Increasing evidence also points to ESCRTs regulating RNA interference (RNAi) pathways that control translation. Copyright © 2013 Elsevier Ltd. All rights reserved.

Citation

Markus Babst, Greg Odorizzi. The balance of protein expression and degradation: an ESCRTs point of view. Current opinion in cell biology. 2013 Aug;25(4):489-94