Hypohidrosis induced by topiramate in an adult patient.

Styliani Karachristianou, Evangelos Papamichalis, Alexandros Sarantopoulos, Panagiota Boura, George Georgiadis

Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece. stellakarax@gmail.com

Epileptic disorders : international epilepsy journal with videotape 2013 Jun

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Hypohidrosis is an uncommon and reversible side effect of topiramate treatment, reported mainly in children. This report presents an adult patient with complex partial seizures who was treated with topiramate and developed hypohidrosis coupled with hyperthermia, related to high environmental temperature and physical exercise. Reduced sweat response was confirmed using the Neuropad test. Signs and symptoms ceased after drug discontinuation. During topiramate treatment, it is important to recognise this side effect, although the exact causal mechanism has not yet been clarified.

Citation

Styliani Karachristianou, Evangelos Papamichalis, Alexandros Sarantopoulos, Panagiota Boura, George Georgiadis. Hypohidrosis induced by topiramate in an adult patient. Epileptic disorders : international epilepsy journal with videotape. 2013 Jun;15(2):203-6