Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

No trivial pursuit! It is not trivial to develop effective small-molecule regulators of protein-protein interactions (PPIs). Moreover, anti-apoptotic Bcl-2 family proteins share similar binding grooves, making it particularly difficult to target them selectively. Despite these challenges, potent and selective inhibitors of individual members of the Bcl-2 family have been successfully developed. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Li Han, Renxiao Wang. Rise of the selective inhibitors of anti-apoptotic bcl-2 family proteins. ChemMedChem. 2013 Sep;8(9):1437-40

PMID: 23907935

View Full Text