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Rise of the selective inhibitors of anti-apoptotic bcl-2 family proteins.

Li Han, Renxiao Wang

State Key Laboratory of Bioorganic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China).

ChemMedChem 2013 Sep


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  • anti- apoptotic proteins (2)
  • bcl 2 (3)
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    No trivial pursuit! It is not trivial to develop effective small-molecule regulators of protein-protein interactions (PPIs). Moreover, anti-apoptotic Bcl-2 family proteins share similar binding grooves, making it particularly difficult to target them selectively. Despite these challenges, potent and selective inhibitors of individual members of the Bcl-2 family have been successfully developed. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

    Citation

    Li Han, Renxiao Wang. Rise of the selective inhibitors of anti-apoptotic bcl-2 family proteins. ChemMedChem. 2013 Sep;8(9):1437-40


    PMID: 23907935

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