Synthesis and evaluation of novel pyrroles and pyrrolopyrimidines as anti-hyperglycemic agents.

M S Mohamed, S A Ali, D H A Abdelaziz, Samar S Fathallah

BioMed research international 2014

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A series of pyrrole and pyrrolopyrimidine derivatives were examined for their in vivo antihyperglycemic activity. Compounds Ia-c,e, and IVg showed promising antihyperglycemic activity equivalent to a well-known standard antihyperglycemic drug, Glimepiride (Amaryl, 4 mg/kg). In this paper, we examine and discuss the structure-activity relationships and antihyperglycemic activity of these compounds.

Citation

M S Mohamed, S A Ali, D H A Abdelaziz, Samar S Fathallah. Synthesis and evaluation of novel pyrroles and pyrrolopyrimidines as anti-hyperglycemic agents. BioMed research international. 2014;2014:249780