Significance and expressions of BRCA1 and BRCA2 protein in sporadic breast cancer].

Jinzhu Ma, Ming Liu

Zhonghua yi xue za zhi 2014 Dec 2

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To explore the role of expressions of BRCA1 and BRCA2 protein in sporadic breast cancer. Eighty-six cases of breast cancer and adjacent cancer tissues and 48 cases of breast hyperplasia surgical specimens were collected. And the immunohistochemical S-P method was employed for detecting the protein expressions of BRCA1 and BRCA2. BRCA1 expression in breast cancer, breast cancer adjacent cancer tissues and positive rates in breast hyperplasia were 60.5% (52/86), 46.5% (40/86) and 100% (48/48). The difference was significant among three groups. The BRCA2 expression in breast cancer, breast cancer adjacent cancer tissues and positive rates in breast hyperplasia were 41.9% (36/86), 55.8% (48/86) and 95.8% (46/48) respectively. And the difference was significant among three groups. The expression of BRCA1 had no obvious relation with BRCA2 protein in breast cancer tissues (r = 0.673, P > 0.05). The aberrant expressions of BRCA1 and BRCA2 protein plays a major role in the occurrence and progression of sporadic breast cancer.

Citation

Jinzhu Ma, Ming Liu. Significance and expressions of BRCA1 and BRCA2 protein in sporadic breast cancer]. Zhonghua yi xue za zhi. 2014 Dec 2;94(44):3515-8