Upregulated TCRζ improves cytokine secretion in T cells from patients with AML.

Previous studies indicated that upregulating TCRζ partially recovers T cell function in patients with leukemia. In this study, we characterized the cytokine profile of TCRζ-transfected T cells from acute myeloid leukemia (AML) patients by QuantibodyArray Glass Chip. Firstly, the significantly lower expression of TCRζ in CD3(+)/TCRζ(+) cells from AML patients was found. Increased secretion of IL-2, IL-8, IL-10, IL-13, IFN-γ, TNF-α, GM-CSF, growth-regulated oncogene (GRO), MIP-1b, and regulated on activation, normal T cell expressed and secreted (RANTES) could be detected in T cells from AML patients after TCRζ upregulating. We concluded that upregulating TCRζ in T cells from AML can alter the secretion profile of cytokines and chemokine which are involved in T cell proliferation and activation.

Citation

Shaohua Chen, Xianfeng Zha, Li Shi, Lingling Zhou, Lijian Yang, Bo Li, Xiuli Wu, Jun Zhong, Tao Zhang, Yuhong Lu, Kanger Zhu, Yangqiu Li. Upregulated TCRζ improves cytokine secretion in T cells from patients with AML. Journal of hematology & oncology. 2015;8:72

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PMID: 26081440

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