Jadomycins, put a bigger ring in it: isolation of seven- to ten-membered ring analogues.

Camilo F Martinez-Farina, David L Jakeman

Chemical communications (Cambridge, England) 2015 Oct 7

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We report the production, isolation, and characterization of jadomycins with seven-, nine-, and ten-membered E-rings, all of which are unique natural product ring scaffolds. This significantly expands the scope of a non-enzymatic biosynthetic step in jadomycin biosynthesis in order to produce novel natural products.

Citation

Camilo F Martinez-Farina, David L Jakeman. Jadomycins, put a bigger ring in it: isolation of seven- to ten-membered ring analogues. Chemical communications (Cambridge, England). 2015 Oct 7;51(78):14617-9