5-Lipoxygenase inhibitor zileuton inhibits Ca(2+)-responses induced by glutoxim and molixan in macrophages.

Z I Krutetskaya, L S Milenina, A A Naumova, V G Antonov, A D Nozdrachev

Doklady. Biochemistry and biophysics 2016 Jul

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Using Fura-2AM microfluorimetry, we have shown for the first time that 5-lipoxygenase specific inhibitor antiasthmatic agent zileuton significantly inhibits Ca(2+)-responses induced by glutoxim and molixan in macrophages. The results support 5-lipoxygenase involvement in the effect of glutoxim and molixan on intracellular Ca(2+) concentration in macrophages and indicate the inadvisability of a combined use of drugs glutoxim and molixan and antiasthmatic agent zileuton.

Citation

Z I Krutetskaya, L S Milenina, A A Naumova, V G Antonov, A D Nozdrachev. 5-Lipoxygenase inhibitor zileuton inhibits Ca(2+)-responses induced by glutoxim and molixan in macrophages. Doklady. Biochemistry and biophysics. 2016 Jul;469(1):302-4