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Rao and colleagues (2017) reveal how Salmonella limits anorexia in mice, protecting them and promoting the spread of infection. The mechanism involves inhibition of the NLRP3 inflammasome limiting vagal nerve stimulation by IL-1β, which in turn promotes appetite. A possible new therapeutic approach for treating anorexia in multiple diseases is proposed. Copyright © 2017 Elsevier Inc. All rights reserved.
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Luke A J O'Neill. The Hunger Games: Salmonella, Anorexia, and NLRP3. Cell metabolism. 2017 Feb 07;25(2):225-226
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PMID: 28178561
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