3,7-Isoquinoline quinones from the ascidian tunicate Ascidia virginea.

A new isoquinoline quinone system and its iodinated derivatives were isolated from the ascidian tunicate Ascidia virginea Müller 1776 (Phlebobranchia: Ascidiidae). Structures were elucidated by spectroscopic methods and derivatization reactions. Ascidine A (3,7-dihydro-1,8-dihydroxy-4-(4'-hydroxyphenyl)isoquinoline-3,7-dione (1), ascidine B (3,7-dihydro-1,8-dihydroxy-4-(4'-hydroxy-3'-iodophenyl)isoquinoline-3,7-dione (2), and ascidine C (3,7-dihydro-1,8-dihydroxy-4-(4'-hydroxy-3',5'-diiodophenyl)isoquinoline-3,7-dione (3) represent a novel type of tyrosine-derived alkaloids.

Citation

Sven T Possner, Frank C Schroeder, Hans Tore Rapp, Volker Sinnwell, Stefan Franke, Wittko Francke. 3,7-Isoquinoline quinones from the ascidian tunicate Ascidia virginea. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2017 Jul 14;72(7-8):259-264

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PMID: 28453442

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