Zhengwen Sun, Qingxia Liu, Huanyu Hong, Haiguang Zhang, Guoqing Zhang
Biochemical and biophysical research communications 2017 Oct 03microRNAs (miRNAs) play critical roles in cancer development and progression. This study investigated the effects of miR-19 in human osteosarcoma (OS) development. Here, we showed that miR-19 was frequently upregulated in OS tissues and cell lines. Moreover the expression of miR-19 was associated with TNM stage, metastasis, size and poor overall survival. Mechanistically, miR-19 dramatically suppressed OS growth in vitro and in vivo. Bioinformatics analyses predicted that SOCS6 is a potential target gene of miR-19 in OS, which was confirmed by luciferase-reporter assay. We also found that SOCS6 expression was downregulated and negatively correlated with miR-19 expression in OS tissues clinically. Moreover, ectopic SOCS6 could reverse miR-19 induced OS growth. Finally, JAK2/STAT3 signaling pathway involves miR-19/SOCS6-mediated OS progression. Together, our data provide important evidence for miR-19 mediated SOCS6 in OS growth and revealed miR-19/SOCS6/JAK2/STAT3 pathway as a potential therapeutic strategy for OS patients. Copyright © 2017. Published by Elsevier Inc.
Zhengwen Sun, Qingxia Liu, Huanyu Hong, Haiguang Zhang, Guoqing Zhang. miR-19 promotes osteosarcoma progression by targeting SOCS6. Biochemical and biophysical research communications. 2017 Oct 03
PMID: 28986253
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