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    Osteosarcoma (OS) is a very aggressive metastatic pediatric and adolescent tumor. Due to its recurrent development of chemotherapy resistance, clinical outcome for OS patients remains poor. Therefore, discovering more effective anticancer agents is needed. Chlorogenic acid (CGA) is a phenolic compound contained in plant-related products that modulates many cellular functions and inhibits cell proliferation in several cancer types. However, few evidence is available in OS. Here, we investigate the effects of CGA in U2OS, Saos-2, and MG-63 OS cells. By multiple approaches, we demonstrate that CGA acts as anticancer molecule affecting the cell cycle and provoking cell growth inhibition mainly by apoptosis induction. We also provide evidence that CGA strongly activates extracellular-signal-regulated kinase1/2 (ERK1/2). Strikingly, ERK1/2 inhibitor PD98059 sensitizes the cells to CGA. Altogether, our data enforce the evidence of the anticancer activity mediated by CGA and provide the rationale for the development of innovative therapeutic strategies in OS cure. © 2019 Wiley Periodicals, Inc.

    Citation

    Luigi Sapio, Alessia Salzillo, Michela Illiano, Angela Ragone, Annamaria Spina, Emilio Chiosi, Severina Pacifico, Michelina Catauro, Silvio Naviglio. Chlorogenic acid activates ERK1/2 and inhibits proliferation of osteosarcoma cells. Journal of cellular physiology. 2020 Apr;235(4):3741-3752

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    PMID: 31602671

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