Successful Haploidentical Stem Cell Transplant With Posttransplant Cyclophosphamide for Isolated Central Nervous System Blast Crisis in a Child With Chronic Myeloid Leukemia.

Goutomi Chatterjee, Neha Rastogi, Dhwanee Thakkar, Rohit Kapoor, Anil Sharma, Satya P Yadav

Journal of pediatric hematology/oncology 2021 Jan

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Chronic myelogenous leukemia (CML) is a myeloproliferative disorder. The extramedullary blast crisis (BC) is a known complication of CML, but it usually accompanies a systemic disease. However, an isolated central nervous system (CNS) BC at relapse is very rare and has a very poor prognosis. Salvage is even more difficult for patients who relapse with a CNS BC after an allogeneic stem cell transplant (SCT). Here, we report successful treatment of an isolated CNS BC of CML in a 14-year-old boy who relapsed with isolated a CNS BC after matched sibling donor SCT by haploidentical SCT with posttransplant cyclophosphamide.

Citation

Goutomi Chatterjee, Neha Rastogi, Dhwanee Thakkar, Rohit Kapoor, Anil Sharma, Satya P Yadav. Successful Haploidentical Stem Cell Transplant With Posttransplant Cyclophosphamide for Isolated Central Nervous System Blast Crisis in a Child With Chronic Myeloid Leukemia. Journal of pediatric hematology/oncology. 2021 Jan;43(1):e146-e147