Diacyl disulfides as the precursors for hydrogen persulfide (H2S2).

Shi Xu, Yingying Wang, Zoel Parent, Ming Xian

Bioorganic & medicinal chemistry letters 2020 Feb 15

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While hydrogen polysulfides (H2Sn, n ≥ 2) are believed to play regulatory roles in biology, their fundamental chemistry and reactivity are still poorly understood. Compounds that can produce H2Sn are useful tools. In this work we found that H2S2 could be effectively produced from diacyl disulfide precursors, triggered by certain nucleophiles, in both aqueous solutions and organic solvents. This method was used to explore redox reactions of H2S2, such as scavenging 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and reduction of tetrazines. Copyright © 2019 Elsevier Ltd. All rights reserved.

Citation

Shi Xu, Yingying Wang, Zoel Parent, Ming Xian. Diacyl disulfides as the precursors for hydrogen persulfide (H2S2). Bioorganic & medicinal chemistry letters. 2020 Feb 15;30(4):126903