Correlation Engine 2.0
Clear Search sequence regions

  • ascomycota (1)
  • colitis (4)
  • colon (2)
  • cytokines (3)
  • dextran (3)
  • diseases and (1)
  • factor (2)
  • family (2)
  • female (1)
  • IL 18 (1)
  • IL 1β (1)
  • inflammasomes (2)
  • M (8)
  • macrophages (3)
  • mice (3)
  • NF κB (2)
  • NLR (2)
  • NLRP3 (6)
  • Pyrin (2)
  • sodium (1)
  • Sizes of these terms reflect their relevance to your search.

    NLRP3 inflammasome may serve as a potential target for the development of novel therapeutics for inflammatory bowel diseases. In this study, we found that Libertellenone M (Lib M), a secondary metabolite from the endophytic fungus Phomopsis sp. S12, has anti-inflammatory potential both in vitro and in vivo. Lib M selectively inhibited the expression of proinflammatory cytokine IL-1β and IL-18 in LPS-activated macrophages. The cleavage of pro-caspase 1 was remarkably reduced by Lib M in macrophages stimulated with three NLRP3 inflammasome activators. Administering Lib M attenuated dextran sulfate sodium-induced experimental acute colitis in mice and significantly reduced the production of these cytokines and cleaved caspase 1 in colon tissues. Apart from inhibition of NLRP3 inflammasome assembly, Lib M also suppressed NF-κB nuclear translocation in macrophages. Taken together, these findings suggest that Lib M-mediated inhibition of NLRP3 inflammasome activation could protect against colitis-like inflammatory diseases, and that this compound derived from a plant-associated fungus might inspire the exploration of novel immunosuppressive agents. Copyright © 2020. Published by Elsevier B.V.


    Minmin Fan, Gang Xiang, Jingwei Chen, Jian Gao, Wenwen Xue, Yixuan Wang, Wuhao Li, Lin Zhou, Ruihua Jiao, Yan Shen, Qiang Xu. Libertellenone M, a diterpene derived from an endophytic fungus Phomopsis sp. S12, protects against DSS-induced colitis via inhibiting both nuclear translocation of NF-κB and NLRP3 inflammasome activation. International immunopharmacology. 2020 Mar;80:106144

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 31927507

    View Full Text