Sayed Haidar Abbas Raza, Rajwali Khan, Linsheng Gui, Nicola M Schreurs, Xiaoyu Wang, Chugang Mei, Xinran Yang, Cheng Gong, Linsen Zan
Bioscience reports 2020 Mar 27The Src homology 2 B 2 (SH2B2) gene regulate energy balance and body weight at least partially by enhancing Janus kinase-2 (JAK2)-mediated cytokine signaling, including leptin and/or GH signaling. Leptin is an adipose hormone that controls body weight. The objective of the present study is to evaluate the association between body measurement traits and SH2B2 gene polymorphisms as responsible mutations. For this purpose, we selected four single-nucleotide polymorphisms (SNPs) in SH2B2 gene, including two in intron 5 (g.20545A>G, and g.20570G>A, one synonymous SNP g.20693T>C, in exon 6 and one in intron 8 (g.24070C>A, and genotyped them in Qinchuan cattle. SNPs in sample populations were in medium polymorphism level (0.250
Sayed Haidar Abbas Raza, Rajwali Khan, Linsheng Gui, Nicola M Schreurs, Xiaoyu Wang, Chugang Mei, Xinran Yang, Cheng Gong, Linsen Zan. Bioinformatics analysis and genetic polymorphisms in genomic region of the bovine SH2B2 gene and their associations with molecular breeding for body size traits in qinchuan beef cattle. Bioscience reports. 2020 Mar 27;40(3)
PMID: 32110807
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