Metabolism of a New Antiaggregant, Indolinone Derivative.

V V Bykov, K A Leonov, V Yu Serebrov, G A Chernysheva, V I Smol'yakova, M A Solov'ev, E V Udut, V P Fisenko, V V Udut

Bulletin of experimental biology and medicine 2020 Apr

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Cytochrome p450-mediated metabolism of GRS (indolinone antiaggregant) and its effects on activities of cytochrome p450 isoenzymes were studied. Inhibition of 6 isomers of cytochrome p450 in human liver microsomes was studied with the use of specific substrates. It was found that human liver cytochrome p450 enzymes could not induce degradation of GRS and that GRS was not an inductor or inhibitor of cytochrome p450 family members 1A2, 2C9, 2C19, 2D6, 2C8, and 3A4. Hence, clinical use of the prospective antiaggregant would not involve the risk of uncontrolled fluctuations in GRS concentrations in the organism because of interactions between the drugs.

Citation

V V Bykov, K A Leonov, V Yu Serebrov, G A Chernysheva, V I Smol'yakova, M A Solov'ev, E V Udut, V P Fisenko, V V Udut. Metabolism of a New Antiaggregant, Indolinone Derivative. Bulletin of experimental biology and medicine. 2020 Apr;168(6):739-742