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BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy.
Prashanthi Ramesh, Jan Paul Medema
Apoptosis : an international journal on programmed cell death 2020 Jun
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Apoptosis is a form of programmed cell death that is essential for tissue homeostasis. De-regulation of the balance between proliferation and apoptosis contributes to tumor initiation. Particularly in the colon where apoptosis is a crucial process in intestinal turnover, inhibition of apoptosis facilitates transformation and tumor progression. The BCL-2 family of proteins are key regulators of apoptosis and have been implicated in colorectal cancer (CRC) initiation, progression and resistance to therapy. In this review we outline the current knowledge on the BCL-2 family-regulated intrinsic apoptosis pathway and mechanisms by which it is de-regulated in CRC. We further review BH3 mimetics as a therapeutic opportunity to target this pathway and evaluate their potential for CRC treatment.
Citation
Prashanthi Ramesh, Jan Paul Medema.
BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy.
Apoptosis : an international journal on programmed cell death.
2020 Jun;25(5-6):305-320
Mesh Tags
Adenocarcinoma
Antineoplastic Agents
Apoptosis
Apoptosis Regulatory Proteins
BH3 Interacting Domain Death Agonist Protein
Colorectal Neoplasms
Gene Expression Regulation, Neoplastic
Humans
Mitochondria
Molecular Mimicry
Myeloid Cell Leukemia Sequence 1 Protein
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Signal Transduction
bcl-2 Homologous Antagonist-Killer Protein
bcl-2-Associated X Protein
bcl-X Protein
Substances
Antineoplastic Agents
Apoptosis Regulatory Proteins
BAK1 protein, human
BAX protein, human
BBC3 protein, human
BCL2 protein, human
BCL2L1 protein, human
BCL2L2 protein, human
BH3 Interacting Domain Death Agonist Protein
BID protein, human
MCL1 protein, human
Myeloid Cell Leukemia Sequence 1 Protein
PMAIP1 protein, human
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
bcl-2 Homologous Antagonist-Killer Protein
bcl-2-Associated X Protein
bcl-X Protein
PMID: 32335811
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