Relinde I Y Lieverse, Damiënne Marcus, Alexander M A van der Wiel, Evert J Van Limbergen, Jan Theys, Ala Yaromina, Philippe Lambin, Ludwig J Dubois
Molecular oncology 2020 JulThe extracellular matrix protein fibronectin contains a domain that is rarely found in healthy adults and is almost exclusively expressed by newly formed blood vessels in tumours, particularly in solid tumours, different types of lymphoma and some leukaemias. This domain, called the extra domain B (ED-B), thus has broad therapeutic potential. The antibody L19 has been developed to specifically target ED-B and has shown therapeutic potential when combined with cytokines, such as IL-2. In this review article, we discuss the preclinical research and clinical trials that highlight the potential of ED-B targeting for the imaging and treatment of various types of cancer. ED-B-centred studies also highlight how proper patient stratification is of utmost importance for the successful implementation of novel antibody-based targeted therapies. © 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
Relinde I Y Lieverse, Damiënne Marcus, Alexander M A van der Wiel, Evert J Van Limbergen, Jan Theys, Ala Yaromina, Philippe Lambin, Ludwig J Dubois. Human fibronectin extra domain B as a biomarker for targeted therapy in cancer. Molecular oncology. 2020 Jul;14(7):1555-1568
PMID: 32386436
View Full Text