Anti-tumor effect of synthetic baicalin-rare earth metal complex drugs on SMMC-7721 cells.

Ming Guo, Xiaoyan Gao, Houhui Song, Yi Gu, Peter Christie, Shengchun Wu, Xiaoyue Fan

Environmental geochemistry and health 2020 Nov

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Baicalin (BC)-rare earth metal complexes [BMCs (BC-Ce, BC-La, and BC-Y)] were synthesized by a complexation coordination method. A mouse tumor model with SMMC-7721 cells was used to examine BMCs for their anti-tumor activities in vivo. The results show that the three new BMCs, Na3Ce (C21H16O11)3·10H2O, Na2La (C21H16O11)2·8H2O, and Na2Y (C21H16O11)2·6H2O significantly inhibited SMMC-7721 cell proliferation, since the BMCs may induce the tumor apoptosis in a dose-dependent manner through decreasing cell membrane fluidity and mitochondrial membrane potential depolarization, blocking of the cell cycle at the G2/M phase, and increasing the expression of Bax and reducing the expression of Bcl-2. The effectiveness order of these three BCMs was as follows: BC-Ce > BC-La > BC-Y > BC. It is concluded that BC-Ce, BC-La, and BC-Y possess potent anti-tumor effects and may be a novel group of anti-tumor drugs. The novel baicalin-rare earth metal complexes (BMC) were synthesized, the anti-tumor effects of the BMC on SMMC-7721 cell analyzed comprehensively.

Citation

Ming Guo, Xiaoyan Gao, Houhui Song, Yi Gu, Peter Christie, Shengchun Wu, Xiaoyue Fan. Anti-tumor effect of synthetic baicalin-rare earth metal complex drugs on SMMC-7721 cells. Environmental geochemistry and health. 2020 Nov;42(11):3851-3864