Patrick Shenjere, Richard Chasty, Anshuman Chaturvedi, Michael W Dennis, Angelia Ong, Daniel H Wiseman, Lia P Menasce
International journal of surgical pathology 2021 MayE-cadherin is expressed in hematopoietic erythroid precursors, but to our knowledge, its expression in blastic plasmacytoid dendritic cell neoplasm (BPDCN) has not been described. We report a case of BPDCN showing strong expression of E-cadherin, arising in a patient with history of primary myelofibrosis. Four more cases of BPDCN tested all showed strong expression of E-cadherin. Lack of awareness of this pattern of expression may lead to erroneous diagnosis of acute erythroid leukemia. It is increasingly becoming important to correctly identify this group of neoplasms, as approved new anti-CD123-targeted therapies are becoming available.
Patrick Shenjere, Richard Chasty, Anshuman Chaturvedi, Michael W Dennis, Angelia Ong, Daniel H Wiseman, Lia P Menasce. E-Cadherin Expression in Blastic Plasmacytoid Dendritic Cell Neoplasms: An Unrecognized Finding and Potential Diagnostic Pitfall. International journal of surgical pathology. 2021 May;29(3):289-293
PMID: 32608312
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