Long non-coding RNAs and MYC association in hematological malignancies.

Leonidas Benetatos, Agapi Benetatou, Georgios Vartholomatos

Annals of hematology 2020 Oct

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Long non-coding RNAs (lncRNAs) have an established role in cell biology. Among their functions is the regulation of hematopoiesis. They characterize the different stages of hematopoiesis in a more lineage-restricted expression pattern than coding mRNAs. They affect hematopoietic stem cell renewal, proliferation, and differentiation of committed progenitors by interacting with master regulators transcription factors. Among these transcription factors, MYC has a prominent role. Similar to MYC's transcriptional activation/amplification of protein coding genes, MYC also regulates lncRNAs' expression profile, while it is also regulated by lncRNAs. Both myeloid and lymphoid malignancies are prone to the association of MYC with lncRNAs. Such interaction inhibits apoptosis, enhances cell proliferation, deregulates metabolism, and promotes genomic instability and resistance to treatment. In this review, we discuss the recent findings that encompass the crosstalk between lncRNAs and describe the pathways that very probably have a pathogenetic role in both acute and chronic hematologic malignancies.

Citation

Leonidas Benetatos, Agapi Benetatou, Georgios Vartholomatos. Long non-coding RNAs and MYC association in hematological malignancies. Annals of hematology. 2020 Oct;99(10):2231-2242