A new benzofuran glycoside from the fruit of Clausena lansium.

Huiting Ao, Xuchao Jia, Lihong Dong, Ruifen Zhang, Lei Liu, Fei Huang, Lixia Wang, Mingwei Zhang

Natural product research 2022 Jan

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In this work, we isolated a new benzofuran glycoside, 6-β-d-glucosyl-6,7-dihydroxy-5-benzofuranpropanoic acid methyl ester (1), together with six known compounds (2-7) from the fruits of Clausena lansium (Lour.) Skeels. Extensive spectroscopic methods were employed to elucidate their structures. Herein, compounds 2, 3, 5 and 6 were reported from Clausena lansium (Lour.) Skeels for the first time. Moreover, compounds 1, 2, 4 and 6 showed comparable 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity to l-ascorbic acid, and compound 4 also exhibited potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and ferric reducing antioxidant power (FRAP). All of the compounds showed oxygen radical absorbance capacity (ORAC) values ranging from 0.3 to 3.6 μmol trolex equivalent/μmol. In addition, compounds 3 and 5 also demonstrated good α-amylase inhibitory activity.

Citation

Huiting Ao, Xuchao Jia, Lihong Dong, Ruifen Zhang, Lei Liu, Fei Huang, Lixia Wang, Mingwei Zhang. A new benzofuran glycoside from the fruit of Clausena lansium. Natural product research. 2022 Jan;36(2):501-507