Inhibition of PTEN activity promotes IB4-positive sensory neuronal axon growth.

Traumatic nerve injuries have become a common clinical problem, and axon regeneration is a critical process in the successful functional recovery of the injured nervous system. In this study, we found that peripheral axotomy reduces PTEN expression in adult sensory neurons; however, it did not alter the expression level of PTEN in IB4-positive sensory neurons. Additionally, our results indicate that the artificial inhibition of PTEN markedly promotes adult sensory axon regeneration, including IB4-positive neuronal axon growth. Thus, our results provide strong evidence that PTEN is a prominent repressor of adult sensory axon regeneration, especially in IB4-positive neurons. © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

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Li-Yu Zhou, Feng Han, Shi-Bin Qi, Jin-Jin Ma, Yan-Xia Ma, Ji-Le Xie, Hong-Cheng Zhang, Xin-Ya Fu, Jian-Quan Chen, Bin Li, Hui-Lin Yang, Feng Zhou, Saijilafu. Inhibition of PTEN activity promotes IB4-positive sensory neuronal axon growth. Journal of cellular and molecular medicine. 2020 Sep;24(18):11012-11017

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PMID: 32744427

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