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JAK/STAT signaling plays a major role in the pathogenesis of secondary hemophagocytic lymphohistiocytosis. This case report on a critically ill patient with secondary hemophagocytic lymphohistiocytosis due to falciparum malaria treated successfully with ruxolitinib, demonstrates that JAK1/2 inhibition might be a promising treatment option for severe cases. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.


André Fuchs, Hans-Martin Orth, Ulrich Germing, Mustafa Kondakci, Martha Holtfreter, Torsten Feldt, Björn Erik-Ole Jensen, Dieter Häussinger. Falciparum malaria-induced secondary hemophagocytic lymphohistiocytosis successfully treated with ruxolitinib. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2020 Nov;100:382-385

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PMID: 32777582

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